Zr–DOTA complex exhibits a compressed, square anti-pris-matic geometry. This is not unusual, since Zr tetraazamacro-cycle complexes exhibit varying geometries dictated by the additional ligands that occupy the coordination sites not occupied by the nitrogen atoms of the macrocycle.25,26,28 The, 89 Zr–DOTA did not undergo transchelation, with a 100-, 500-, and 1000-fold excess of EDTA at pH 5 or pH 7 over 7 days. In contrast, 89 Zr–DFO completely lost metal ions after 3 h incubation, with a 1000-fold excess of EDTA at pH 5.
We report our initial investigations into the use of tetraazamacrocycles as zirconium-89 chelators. We describe the synthesis and complete characterization of several Zr tetraazamacrocycle complexes, and definitively describe the first crystal structure of zirconium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid ( Zr-DOTA ) using single crystal X-ray diffraction analysis.
More recently, Pandya et al. showed that [89 Zr] Zr-DOTA was superior to [89 Zr]Zr-DFO. Although the in vitro stability of 89 Zr-DOTA seems higher to that of [89 Zr]Zr-4HMS, biodistribution data for both chelators were quite similar. The elevated temperature needed for [89 Zr] Zr-DOTA complexation may be a potential limitation for immune-PET …
About a team: Game: Dota 2 Team Country: France. Overall Winrate: 28.57% Last 10 Matches Winrate: 28.57% ZR takes #123 place in the ranking having CQ.Score = 1355, 5/1/2018 · Introduction: The development of bifunctional chelators (BFCs) that can stably chelate zirconium-89 (89 Zr) while being conjugated to targeting molecules is an area of active research (1). A recent publication described the extraordinary stability of the radiolabeled tetraazamacrocycle, 89 Zr-DOTA in vivo (2). This work extends this research and examines the influence of macrocycle structure …
5 N N N N DOTA Zr-DOTA MeOH Reflux, 3 h ZrAcAc 94% OH HO OH HO O O O O N N N N Zr O O O O O O O O Scheme S1. Synthesis of zirconium complex of DOTA Synthesis of Zr-DOTA . ZrAcAc (702 mg, 1.44 mmol) was added to a solution of DOTA (529 mg, 1.31 mmol)
